March 1, 1968Canadian Journal of Physiology and Pharmacology
Removal of angiotensins from the systemic circulation
Why the study?
Does tissue extraction clear angiotensin from the systemic circulation in normal anesthetized dogs and rats?
Population
Normal anesthetized dogs and rats
Comparison
Infusions of α-angiotensin and its… vs Infusions into the efferent vessel of each organ
Design
Preclinical
Authors
Discussion
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Implication
Angiotensin clearance in animal peripheral beds warrants no clinical change; leaves open human translation and mechanisms.
Key Points
- To evaluate the clearance of α-angiotensin and its aminopeptidase-resistant analogue β-angiotensin across pulmonary, hepatoportal, femoral, and renal vascular beds.
- Conducted physiological infusion experiments in normal anesthetized dogs and rats.
- Administered α-angiotensin and β-angiotensin into afferent and efferent blood vessels across pulmonary, hepatoportal, femoral, and renal vascular beds to compare systemic pressor responses.
- Extraction of both α-angiotensin and β-angiotensin across the pulmonary circulation was negligible.
- Extraction across the hepatoportal, femoral, and renal vascular beds averaged 70% for α-angiotensin and 63% for the β-analogue.
Structured PICO
Does tissue extraction clear angiotensin from the systemic circulation in normal anesthetized dogs and rats?
P
Population
Normal anesthetized dogs and rats
I
Intervention
Infusions of α-angiotensin and its aminopeptidase-resistant analogue β-angiotensin into the afferent vessel of pulmonary, hepatoportal, femoral, and renal vascular beds
C
Comparator
Infusions into the efferent vessel of each organ
O
Outcome
Systemic pressor responses to calculate extraction percentagesurrogate
The clearing of angiotensin from the systemic circulation primarily occurs in tissues rather than through circulating angiotensinases.
Cite This Study
Biron et al. (1968) studied this question.