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June 1, 1980Endocrinology

Properties of Angiotensin II Receptors of Isolated Rat Glomeruli: Factors Influencing Binding Affinity and Comparative Binding of Angiotensin Analogs*

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Population

Isolated rat glomeruli, adrenal glomerulosa, and uterine smooth muscle

Design

Preclinical

Authors

GBGregory P. BrownMacquarie UniversityJDJ G DouglasCommunity Health Partnership

Discussion

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Overview

Rat glomerular angiotensin II receptors resemble adrenal more than uterine; leaves open tissue-specific subtype distinctions for cardiovascular research.

Structured PICO

P
Population
Isolated rat glomeruli, adrenal glomerulosa, and uterine smooth muscle
I
Intervention
[125I]angiotensin II and angiotensin analogs
O
Outcome
Binding affinity (equilibrium association constants) and receptor concentrationssurrogate

Isolated rat glomeruli possess a single class of high-affinity angiotensin II receptors that share more properties with adrenal glomerulosa than with uterine smooth muscle.

Cite This Study

Brown et al. (1980) studied this question.

synapsesocial.com/papers/6a8932eb055af99351621171https://doi.org/10.1210/endo-106-6-1923
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II binding to renal glomeruli from sodium-loaded and sodium-depleted rats1976 · 52 citations
  2. 2Angiotensin antagonists with increased specificity for the renal vasculature.1977 · 37 citations
  3. 3Angiotensin II Receptors and Aldosterone Production in Rat Adrenal Glomerulosa Cells1978 · 139 citations
  4. 4PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT1951 · 318,692 citations
  5. 5Comparative Receptor-Binding Properties of Heptapeptide and Octapeptide Antagonists of Angiotensin II in Rat Adrenal Glomerulosa and Uterine Smooth Muscle*1980 · 19 citations