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May 1, 1976American Journal of Physiology-Legacy Content

Angiotensin II binding to renal glomeruli from sodium-loaded and sodium-depleted rats

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Why the study?

Does sodium loading alter angiotensin II binding in isolated rat glomeruli compared to sodium depletion?

Population

Isolated rat glomeruli from acutely and chronically sodium-loaded and sodium-depleted rats

Comparison

Sodium loading (acute and chronic) vs Sodium depletion (acute and chronic)

Design

Preclinical

Authors

MBM BeaufilsSorbonne UniversitéJSJean–Daniel SraerInsermCLC LepreuxInserm

Discussion

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Implication

Sodium balance may modulate glomerular angiotensin II receptors in rats; leaves open any role in human renal sodium handling or GFR adaptation.

Structured PICO

Does sodium loading alter angiotensin II binding in isolated rat glomeruli compared to sodium depletion?

P
Population
Isolated rat glomeruli from acutely and chronically sodium-loaded and sodium-depleted rats
I
Intervention
Sodium loading (acute and chronic)
C
Comparator
Sodium depletion (acute and chronic)
O
Outcome
Angiotensin II binding (number of receptor sites and affinity/KD)surrogate

Sodium balance modulates both the number and affinity of angiotensin II receptors in rat glomeruli, suggesting a role in adapting glomerular filtration rate to sodium status.

Cite This Study

Beaufils et al. (1976) studied this question.

synapsesocial.com/papers/6a70d66735aa2c282ce22951https://doi.org/10.1152/ajplegacy.1976.230.5.1187
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II Receptors in Human Isolated Renal Glomeruli*1982 · 14 citations
  2. 2Properties of Angiotensin II Receptors of Isolated Rat Glomeruli: Factors Influencing Binding Affinity and Comparative Binding of Angiotensin Analogs*1980 · 50 citations
  3. 3The binding of [125I]‐angiotensin to rat renal epithelial cell membranes1983 · 15 citations
  4. 4Angiotensin II Receptor Heterogeneity1991 · 63 citations
  5. 5Angiotensin II Binding Sites on Isolated Rat Renal Brush Border Membranes*1982 · 104 citations