Key result
Rat renal brush border membranes contain high affinity specific binding sites for angiotensin II, with MgCl2 increasing binding site concentration from 162 to 597 fmol/mg protein.
This study provides the first characterization of high-affinity specific binding sites for angiotensin II in rat renal brush border membranes, which are modulated by sodium and magnesium.
No takes yet. Share an insight, caveat, or question.
Advances basic understanding of renal angiotensin II actions; leaves open any clinical relevance in humans.
Brown et al. (1982) studied this question. NaCl and MgCl2 was evaluated on Specific binding of [125I]iodo-angiotensin II at steady state. Rat renal brush border membranes contain high affinity specific binding sites for angiotensin II, with MgCl2 increasing binding site concentration from 162 to 597 fmol/mg protein.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: