Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1979Endocrinology

Comparative Studies of Receptor Binding and Steroidogenic Properties of Angiotensins in the Rat Adrenal Glomerulosa*

View Full Paper
Ask AI
Bookmark
Share

Population

Isolated rat adrenal zona glomerulosa cells

Comparison

Angiotensin and analogs vs Various angiotensin analogs compared to each other

Design

Preclinical

Authors

JDJanice G. DouglasSt. Michael's HospitalMMMichail Lubomirov MichailovNational Sports Academy Vassil LevskiMKM. C. KhoslaColumbia University

Discussion

Loading...

Member takes

Implication

Validates receptor affinity screening in rodent models; extends mechanistic insights but leaves open human translation.

Structured PICO

P
Population
Isolated rat adrenal zona glomerulosa cells
I
Intervention
Angiotensin and analogs (e.g., [Asp1, Ile5]angiotensin II, [Asp1, Val5]angiotensin II, [Sar1]angiotensin II, etc.)
C
Comparator
Various angiotensin analogs compared to each other
O
Outcome
Correlation between receptor affinity and steroidogenic potency (aldosterone-releasing effect)surrogate

In rat adrenal glomerulosa cells, the receptor binding affinity of angiotensin analogs correlates significantly with their aldosterone-releasing potency.

Cite This Study

Douglas et al. (1979) studied this question.

synapsesocial.com/papers/6a86df89f87adc0a02ca1498https://doi.org/10.1210/endo-104-1-71
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II Receptors and Aldosterone Production in Rat Adrenal Glomerulosa Cells1978 · 139 citations
  2. 2Angiotensin II- and Angiotensin III-Induced Aldosterone Release in vivo in the Rat1974 · 109 citations
  3. 3Angiotensin III: (DES-Aspartic Acid-1)-Angiotensin II. Evidence and speculation for its role as an important agonist in the renin - angiotensin system.1975 · 116 citations
  4. 4DES-ASP1-Angiotensin II: Possible Role in Mediating Responses of the Renin-Angiotensin System1975 · 10 citations
  5. 5<b>Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide</b>1963 · 7,659 citations