Population
Isolated rat and canine adrenal glomerulosa cells
Comparison
Angiotensin II and des-Asp1-angiotensin II vs Comparison between the two peptides
Design
Preclinical
Follow-up
up to 120 minutes (incubation)
Authors
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Species differences in angiotensin degradation explain potency variations; leaves open human relevance of direct Ang II aldosterone stimulation.
Angiotensin II stimulates aldosterone production in rat and dog glomerulosa cells without requiring prior conversion to the heptapeptide, with apparent potency differences driven by species-specific peptide metabolism rates.
Aguilera et al. (1979) studied this question.