Key result
Both [Sar1,Ala8]angiotensin II and [Sar1,Ile8]angiotensin II inhibited aldosterone response to angiotensin II, but only [Sar1,Ile8]angiotensin II inhibited the response to ACTH.
[Sar1,Ile8]angiotensin II exhibits non-specific inhibition of ACTH-induced aldosterone secretion compared to [Sar1,Ala8]angiotensin II in rat zona glomerulosa cells.
Non-specific ACTH inhibition by [Sar1,Ile8]angiotensin II in rat cells warrants caution in analog selection; leaves open specificity for human studies.
Isolated perfused rat zona glomerulosa cells have been used to determine the specificity of the angiotensin II antagonists, [Sar1,Ala8]angiotensin II and [Sar1,Ile8]angiotensin II. Both antagonists inhibited the aldosterone response to angiotensin II but did not affect serotonin- or potassium-induced aldosterone secretion. However, in contrast to [Sar1,Ala8]angiotensin II, [Sar1,Ile8]angiotensin II inhibited the aldosterone response to ACTH. These results suggest that there are differences in the specificity of these two analogs and that studies with [Sar1,Ile8]angiotensin II and its effect on aldosterone secretion should be interpreted with caution.
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Boscaro et al. (1981) studied this question. [Sar1,Ala8]angiotensin II and [Sar1,Ile8]angiotensin II was evaluated on Aldosterone response to angiotensin II, serotonin, potassium, and ACTH. Both [Sar1,Ala8]angiotensin II and [Sar1,Ile8]angiotensin II inhibited aldosterone response to angiotensin II, but only [Sar1,Ile8]angiotensin II inhibited the response to ACTH.
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