Why the study?
Does angiotensin II compared to Des1-angiotensin II differentially affect blood pressure, plasma renin activity, and plasma aldosterone in normal anaesthetized dexamethasone-suppressed dogs?
Population
Normal anaesthetized dexamethasone-suppressed dogs
Comparison
Infusions of equimolar doses of angiotensin II vs Infusions of equimolar doses of Des1-angiotensin…
Design
Preclinical
Authors
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Challenges heptapeptide primacy in aldosterone secretion in dogs; leaves open human relevance versus angiotensin II.
Does angiotensin II compared to Des1-angiotensin II differentially affect blood pressure, plasma renin activity, and plasma aldosterone in normal anaesthetized dexamethasone-suppressed dogs?
The study demonstrates differences between the effects of angiotensin II and its heptapeptide on blood pressure and aldosterone, challenging the hypothesis that the heptapeptide is the main mediator of aldosterone secretion.
Beckerhoff et al. (1976) studied this question.
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