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November 1, 1968Endocrinology

Sensitivity to Angiotensin and Adrenocorticotrophic Hormone in the Sodium Deficient Rat

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Why the study?

Does sodium deficiency sensitize the adrenal response to angiotensin and ACTH in rats?

Population

Acutely hypophysectomized-nephrectomized rats, either sodium replete or sodium deficient

Comparison

Infusion of angiotensin and… vs Sodium replete animals, and single hormone…

Design

Preclinical

Authors

GKGordon A. KinsonUniversity of OttawaBSBertha SingerMcGill University

Discussion

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Implication

Sodium deficiency may sensitize adrenal responses in rats; leaves open translation to human sodium balance or hypertension.

Key Points

  • To determine how dietary sodium deficiency alters the adrenal secretory response to angiotensin and ACTH, administered individually and in combination.
  • Studied acutely hypophysectomized-nephrectomized rats maintained on a sodium-deficient diet for one week versus sodium-replete controls.
  • Infused animals with angiotensin alone, ACTH alone, or both hormones simultaneously.
  • Measured aldosterone and corticosterone secretion rates in adrenal vein blood using the double isotope method.
  • Angiotensin infusion produced a significant increase in aldosterone secretion without altering corticosterone in sodium-deficient rats, whereas it had no significant effect on either hormone in sodium-replete rats.
  • ACTH stimulated both aldosterone and corticosterone in both dietary groups, but combined infusion with angiotensin in sodium-deficient rats produced a synergistic increase in aldosterone secretion exceeding the sum of separate responses.

Structured PICO

Does sodium deficiency sensitize the adrenal response to angiotensin and ACTH in rats?

P
Population
Acutely hypophysectomized-nephrectomized rats, either sodium replete or sodium deficient (produced by 1 week of dietary salt restriction)
I
Intervention
Infusion of angiotensin and adrenocorticotrophin (ACTH), singly and together
C
Comparator
Sodium replete animals, and single hormone infusions
O
Outcome
Rate of secretion of aldosterone and corticosterone into adrenal vein bloodsurrogate

Sodium deficiency in rats sensitizes the aldosterone secreting mechanism to angiotensin, supporting its role in the adrenal response to sodium deficiency.

Cite This Study

Kinson et al. (1968) studied this question.

synapsesocial.com/papers/6a7708cee539f649abf6d700https://doi.org/10.1210/endo-83-5-1108
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Renin-Angiotensin System and Aldosterone Secretion during Sodium Depletion in the Rat1974 · 63 citations
  2. 2Role of Angiotensin II in the Aldosterone Secretory Response to Adrenocorticotropin in Sodium-Restricted Normal Human Subjects*1978 · 7 citations
  3. 3Control of aldosterone secretion during sodium restriction: Adrenal receptor regulation and increased adrenal sensitivity to angiotensin II1978 · 122 citations
  4. 4Effect of Sodium Deficiency onβ-Melanocyte-Stimulating Hormone Stimulation of Aldosterone in Isolated Rat Adrenal Cells1983 · 16 citations
  5. 5Rat model for investigating ACTH-independent angiotensin-induced aldosterone secretion2000 · 5 citations