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July 1, 1980European Journal of Endocrinology

Role of the renin-angiotensin system in the adaptation of aldosterone biosynthesis to sodium restriction in the rat

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Why the study?

Does angiotensin converting enzyme inhibition reduce aldosterone biosynthesis in sodium-depleted rats?

Population

Rats kept on a control or low-sodium diet for one week

Comparison

Angiotensin converting enzyme inhibitor SQ… vs Empty subcutaneous osmotic minipumps

Design

Preclinical

Follow-up

23 hours post-implantation

Authors

ÉTÉ. TarjánMedical University of GrazASAndrás SpätSemmelweis UniversityTBTamás BallaNational Institutes of Health

Discussion

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Implication

ACE inhibition blunts aldosterone response to sodium restriction in rats; leaves open translation to human sodium-depleted states.

Structured PICO

Does angiotensin converting enzyme inhibition reduce aldosterone biosynthesis in sodium-depleted rats?

P
Population
Rats kept on a control or low-sodium diet for one week
I
Intervention
Angiotensin converting enzyme inhibitor (CEI) SQ 20,881 infused via subcutaneous osmotic minipumps for 23 hours
C
Comparator
Empty subcutaneous osmotic minipumps
O
Outcome
Serum aldosterone level and conversion of [3H]corticosterone to [3H]aldosterone in adrenal capsular tissuesurrogate

Inhibition of the renin-angiotensin system significantly blunts aldosterone biosynthesis and secretion in response to sodium restriction in rats.

Cite This Study

Tarján et al. (1980) studied this question.

synapsesocial.com/papers/6a907d0dc63bb9fb07dd9436https://doi.org/10.1530/acta.0.0940381
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Renin-Angiotensin System and Aldosterone Secretion during Sodium Depletion in the Rat1974 · 63 citations
  2. 2Role of adrenal renin-angiotensin system in the control of aldosterone secretion in sodium-restricted rats2000 · 41 citations
  3. 3Sodium-Mediated Modulation of Aldosterone Secretion: Impact of Converting Enzyme Inhibition on Rat Glomerulosa Cell Response to Angiotensin-II*1989 · 7 citations
  4. 4Primacy of the Renin-Angiotensin System in Mediating the Aldosterone Response to Sodium Restriction*1980 · 42 citations
  5. 5Role of Tissue Renin in the Regulation of Aldosterone Biosynthesis in the Adrenal Cortex of Nephrectomized Rats1997 · 32 citations