Key result
In rats with chronic salt depletion, renal mechanisms independent of catecholamines or aldosterone ensured maximal salt conservation, although losartan significantly increased sodium excretion.
Population
Rats subjected to negative salt balance via intraperitoneal furosemide followed by a low-salt diet
Comparison
6-hydroxydopamine to destroy sympathetic… vs Control group and sham-adrenalectomized group
Design
Preclinical
Follow-up
1 week
Authors
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Challenges necessity of aldosterone/catecholamines for maximal renal salt conservation; leaves open whether losartan natriuresis applies in human depletion.
During chronic salt depletion in rats, maximal renal salt conservation can occur independently of neuronally released catecholamines, circulating catecholamines, or aldosterone.
Honrath et al. (1997) studied Chronic salt depletion. Sympathetic and angiotensin-aldosterone system blockade or ablation (OHDA, losartan, adrenal enucleation, adrenalectomy) vs. Control and sham-adrenalectomized rats was evaluated on Steady-state urinary salt excretion. In rats with chronic salt depletion, renal mechanisms independent of catecholamines or aldosterone ensured maximal salt conservation, although losartan significantly increased sodium excretion.
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