Why the study?
Does centrally administered angiotensin II alter salt and water excretion in adult male rats?
Population
Adult male rats (n = 34) acclimated to metabolism cages
Comparison
0.5 µg angiotensin intraventricularly in 5 µl… vs 5 µl artificial cerebrospinal fluid…
Design
Preclinical, Every rat was randomly exposed to each of 3 test procedures
Follow-up
3 hours
Authors
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No clinical implications in humans; leaves open central angiotensin effects on mammalian fluid balance.
Does centrally administered angiotensin II alter salt and water excretion in adult male rats?
Centrally administered angiotensin II in rats induces drinking, antidiuresis, and sodium/potassium loss, suggesting it may cause the central nervous system to perceive a state of hyperosmolality.
Severs et al. (2008) studied this question.
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