Effects of hypotension and fluid depletion on central angiotensin-induced thirst and salt appetite

Thunhorst et al. (2001) studied this question. Hypotension and fluid depletion vs. Fluid-replete state / baseline was evaluated on Water and sodium ingestion. Hypotension in fluid-replete rats preferentially increased water intake in response to central ANG II, whereas in fluid-depleted rats it increased both salt and water intake.