Why the study?
Does circulating angiotensin II mediate sodium appetite in adrenalectomized rats?
Population
Adrenalectomized rats deprived of their main access to sodium (0.3 M NaCl) for 9 h or 22 h
Comparison
Intravenous infusion of captopril with or… vs Adrenalectomized rats not treated with captopril
Design
Preclinical
Authors
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Should not change clinical sodium management; leaves open translational relevance of circulating angiotensin II in adrenalectomized models.
Does circulating angiotensin II mediate sodium appetite in adrenalectomized rats?
Circulating angiotensin II mediates most or all of the sodium appetite in adrenalectomized rats.
Schoorlemmer et al. (2001) studied this question.
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