Key result
High-dose captopril decreased sodium intake in sodium-depleted mice by 80-85%, an effect that was restored to initial levels by concurrent angiotensin II infusion.
In a mouse model, angiotensin II appears to be involved in the sodium appetite of sodium-depleted mice, but not in water intake.
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Angiotensin II may drive sodium appetite in depleted states in mice; human relevance and therapeutic implications remain untested.
Weisinger et al. (1990) studied Na-depletion-induced Na appetite. Captopril was evaluated on Na intake. High-dose captopril decreased sodium intake in sodium-depleted mice by 80-85%, an effect that was restored to initial levels by concurrent angiotensin II infusion.
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