Population
Rats with bilateral ureteric ligation, adrenalectomized rats, and deoxycorticosterone-treated rats
Design
Preclinical
Authors
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Cautions against generalizing ACE-inhibitor effects on sodium appetite across rat models; leaves open renin dependence in human cardiorenal states.
The effect of captopril on sodium appetite in rats depends on its ability to increase plasma renin, suggesting sodium appetite is renin-dependent in adrenalectomized rats but not in deoxycorticosterone-treated rats.
Elfont et al. (1985) studied this question.
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