Why the study?
Does captopril alter fluid and electrolyte balances and adrenocortical responses in sodium-deprived rats?
Does captopril alter fluid and electrolyte balances and adrenocortical responses in sodium-deprived rats?
Captopril prevents the normal physiological adaptations to sodium deprivation in rats, leading to negative sodium balance and blunted aldosterone response.
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Captopril blunts sodium conservation and aldosterone responses in deprived rats; leaves open translation to human ACE inhibitor use during sodium restriction.
McKeever et al. (1983) studied this question.
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