Key result
Intravenous infusion of captopril at 1.0 mg/kg/h over 24 hours decreased sodium intake by 45-55% in sodium-deplete sheep, an effect restored by concurrent intravenous angiotensin II.
Population
Na-deplete sheep
Comparison
Intravenous infusion of captopril alone or with… vs Base-line level / absence of infusion
Design
Preclinical
Follow-up
up to 24 hours
Authors
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Should not alter ACE inhibitor use in patients; leaves open translation of peripheral angiotensin II effects on sodium appetite beyond this ovine model.
The renin-angiotensin system is involved in the sodium appetite of sodium-deplete sheep, likely acting via a circumventricular organ lacking a blood-brain barrier.
Weisinger et al. (1987) studied Sodium depletion. Captopril vs. Baseline was evaluated on Sodium intake. Intravenous infusion of captopril at 1.0 mg/kg/h over 24 hours decreased sodium intake by 45-55% in sodium-deplete sheep, an effect restored by concurrent intravenous angiotensin II.
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