Key result
Intravenous angiotensin II increases sodium intake ~28% while captopril reduces it in sodium-depleted cows.
Why the study?
The mechanisms by which angiotensin II regulates sodium appetite and thirst in sodium-depleted cattle were unclear, particularly regarding receptor accessibility.
Population
Cows depleted of Na by loss of saliva from a parotid fistula for 46 h
Comparison
Intravenous or intracerebroventricular infusion of angiotensin II or captopril versus no infusion
Design
Preclinical experimental study
Follow-up
3 hours
Authors
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Alerts clinicians to species-specific sodium regulation; extends angiotensin II appetite findings to ruminants but leaves open human applicability.
Absolute Event Rate: 26.8% vs 21%
p-value: p=<0.01
In sodium-depleted cows, intravenous angiotensin II stimulates sodium appetite while intravenous captopril inhibits it, suggesting peripheral angiotensin II receptors regulate sodium appetite.
Blair‐West et al. (1988) studied Sodium depletion. Intravenous or intracerebroventricular angiotensin II or captopril vs. Baseline sodium-depleted state was evaluated on Sodium intake (liters of 0.3 M NaHCO3-NaCl solution) (p=<0.01). Intravenous angiotensin II increased sodium intake to 26.8 L (P<0.01), whereas intravenous captopril reduced sodium intake to 11.0 L (P<0.001) in sodium-depleted cows.
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