April 1, 1980The Journal of PhysiologyOpen Access

Arousal of a specific and persistent sodium appetite in the rat with continuous intracerebroventricular infusion of angiotensin II.

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Population

Normal Na-replete rats

Comparison

Continuous intracerebroventricular infusion of… vs Uninfused rats given saccharine-flavoured water…

Design

Preclinical

Follow-up

up to 7 months

Authors

RBRichard W. BryantRutgers, The State University of New Jersey AEA. N. EpsteinUniversity of the Sciences JFJ. T. FitzsimonsUniversity of Cambridge

Discussion

Member takes

Implication

Extends central angiotensin II effects on salt appetite in rats; leaves open translation to human fluid disorders or hypertension.

Structured PICO

Population

Normal Na-replete rats

Intervention

Continuous intracerebroventricular infusion of angiotensin II (dose range 6 ng h-1 to 6000 ng h-1), short-term repeated systemic injections of isoprenaline or renin, and repeated intracranial injections of angiotensin II

Comparator

Uninfused rats given saccharine-flavoured water, or rats intragastrically infused with water

Outcome

Ingestion of NaCl (2.7% or 3%) and watersurrogate

Continuous intracerebroventricular infusion of angiotensin II in rats induces a specific, dose-dependent, and persistent sodium appetite.

Cite This Study

Bryant et al. (1980) studied this question.

synapsesocial.com/papers/6a87e334f455bdf6826c936d https://doi.org/10.1113/jphysiol.1980.sp013211

View Full Paper

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Arousal of a specific and persistent sodium appetite in the rat with continuous intracerebroventricular infusion of angiotensin II.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Arousal of a specific and persistent sodium appetite in the rat with continuous intracerebroventricular infusion of angiotensin II.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider