Key result
Intracerebroventricular infusion of angiotensin II at 70 ng/day significantly increased intakes of NaCl solution and water by the third day of infusion (P<0.05) in BALB/c mice.
Why the study?
Does systemic or intracerebroventricular administration of angiotensin II increase intakes of NaCl solution, water, and food in BALB/c mice?
Does systemic or intracerebroventricular administration of angiotensin II increase intakes of NaCl solution, water, and food in BALB/c mice?
p-value: p=<0.05
Intracerebroventricular infusion of angiotensin II directly stimulates neural systems involved in sodium appetite and water intake in BALB/c mice.
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Hypothesis-generating for central angiotensin II effects on sodium appetite in mice; leaves open translation to human cardiovascular physiology.
Denton et al. (1990) studied this question. Angiotensin II vs. Systemic administration was evaluated on Intakes of NaCl solution, water, and food (p=<0.05). Intracerebroventricular infusion of angiotensin II at 70 ng/day significantly increased intakes of NaCl solution and water by the third day of infusion (P<0.05) in BALB/c mice.
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