July 1, 1979Endocrinology

Adrenal Hormones and the Regulation of Serum Potassium in Potassium-Loaded Adrenalectomized Dogs*

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Why the study?

Do adrenal hormones improve tolerance to potassium loading in adrenalectomized dogs?

Population

Adrenalectomized dogs infused with 2 meq KCl/kg/h

Comparison

Treatment with adrenal hormones vs Intact control dogs and untreated…

Design

Preclinical

Authors

NHN. HiattCedars-Sinai Medical Center LCLloyd W. ChapmanUniversity of Southern California MDMayer B. DavidsonVenice Family Clinic

Discussion

Member takes

Overview

Adrenal hormone effects in dogs should not yet change practice; extends mechanistic insights into K+ tolerance but requires human validation.

Structured PICO

Do adrenal hormones improve tolerance to potassium loading in adrenalectomized dogs?

Population

Adrenalectomized dogs infused with 2 meq KCl/kg/h

Intervention

Treatment with adrenal hormones (aldosterone, dexamethasone, hydrocortisone, or epinephrine)

Comparator

Intact control dogs and untreated adrenalectomized dogs

Outcome

Tolerance to KCl infusion (measured by potassium transfer to intracellular fluid, urinary potassium loss, and cardiac sensitivity to potassium)surrogate

Adrenal hormones regulate potassium tolerance through distinct mechanisms: epinephrine promotes intracellular potassium shift, while glucocorticoids enhance renal excretion and reduce cardiac sensitivity to hyperkalemia.

Cite This Study

Hiatt et al. (1979) studied this question.

synapsesocial.com/papers/6a761a97f1e99ff85ab2380b https://doi.org/10.1210/endo-105-1-215

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July 1, 1979Endocrinology

Adrenal Hormones and the Regulation of Serum Potassium in Potassium-Loaded Adrenalectomized Dogs*

View Full Paper

Ask AI

Bookmark

Why the study?

Do adrenal hormones improve tolerance to potassium loading in adrenalectomized dogs?

Population

Adrenalectomized dogs infused with 2 meq KCl/kg/h

Comparison

Treatment with adrenal hormones vs Intact control dogs and untreated…

Design

Preclinical

Authors

NHN. HiattCedars-Sinai Medical Center LCLloyd W. ChapmanUniversity of Southern California MDMayer B. DavidsonVenice Family Clinic

Discussion

Member takes

Overview

Adrenal hormone effects in dogs should not yet change practice; extends mechanistic insights into K+ tolerance but requires human validation.

Structured PICO

Do adrenal hormones improve tolerance to potassium loading in adrenalectomized dogs?

Population

Adrenalectomized dogs infused with 2 meq KCl/kg/h

Intervention

Treatment with adrenal hormones (aldosterone, dexamethasone, hydrocortisone, or epinephrine)

Comparator

Intact control dogs and untreated adrenalectomized dogs

Outcome

Tolerance to KCl infusion (measured by potassium transfer to intracellular fluid, urinary potassium loss, and cardiac sensitivity to potassium)surrogate

Cite This Study

Hiatt et al. (1979) studied this question.

synapsesocial.com/papers/6a761a97f1e99ff85ab2380b https://doi.org/10.1210/endo-105-1-215

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

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