Why the study?
Does ACTH inhibition or potassium administration affect plasma aldosterone concentration in patients with primary aldosteronism?
Does ACTH inhibition or potassium administration affect plasma aldosterone concentration in patients with primary aldosteronism?
In primary aldosteronism due to adrenal adenoma, plasma aldosterone is relatively more sensitive to small changes in ACTH than to angiotensin or potassium levels.
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ACTH suppression may lower aldosterone in adenoma patients; leaves open potassium's role pending prospective confirmation.
Ganguly et al. (1982) studied this question.
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