Why the study?
Does the plasma aldosterone response to angiotensin II infusion differ between patients with aldosterone-producing adenoma and idiopathic hyperaldosteronism?
Population
17 patients with primary aldosteronism
Comparison
Graded doses of angiotensin II infusion vs Aldosterone-producing adenoma versus idiopathic…
Design
Cohort
Authors
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May aid APA versus IHA subtyping in primary aldosteronism; leaves open prospective validation before clinical use.
Does the plasma aldosterone response to angiotensin II infusion differ between patients with aldosterone-producing adenoma and idiopathic hyperaldosteronism?
Patients with aldosterone-producing adenomas have significantly lower adrenal sensitivity to angiotensin II compared to those with idiopathic hyperaldosteronism, which may explain differences in postural responses.
Wisgerhof et al. (1981) studied this question.
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