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July 1, 1975The Journal of Clinical Endocrinology & Metabolism

Potassium-Aldosterone-Renin Interrelationships

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Why the study?

Do small physiologic changes in plasma potassium concentration affect the renin-angiotensin-aldosterone axis in normal subjects?

Population

8 normal subjects on a 10 meq sodium-100 meq potassium intake and 6 normal subjects

Comparison

Graded constant infusions of potassium chloride… vs Baseline/control levels prior to infusion or…

Design

Other

Follow-up

2 hours

Authors

THThep HimathongkamBangkok HospitalRDRobert G. DluhyHarvard UniversityGWGordon H. WilliamsPreventive Cardiology

Discussion

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Implication

Small K shifts may alter aldosterone readings; leaves open relevance to RAAS-targeted care.

Key Points

  • This study aims to assess how small changes in plasma potassium affect the renin-angiotensin-aldosterone axis in healthy individuals.
  • Infusions of potassium chloride were administered over 2 hours to 8 normal subjects.
  • Plasma levels of aldosterone, renin, angiotensin II, cortisol, potassium, and sodium were measured.
  • The potassium-lowering effect of glucose ingestion was evaluated in six additional normal subjects.
  • During the lowest infusion rate of potassium (0.17 meq/min), plasma aldosterone rose by 46% (mean increment 13 ng/100 ml) at 30-60 minutes.
  • The study identifies a sensitive dose-response range for potassium at 0.1-0.5 meq/liter, with stepwise increases in both potassium and aldosterone.
  • Glucose ingestion reduced potassium levels by 8% (mean decrement 0.3 meq/liter), coinciding with a significant decline in plasma aldosterone of 46% (11 ng/100 ml).

Structured PICO

Do small physiologic changes in plasma potassium concentration affect the renin-angiotensin-aldosterone axis in normal subjects?

P
Population
8 normal subjects on a 10 meq sodium-100 meq potassium intake (for potassium infusion) and 6 normal subjects (for glucose ingestion)
I
Intervention
Graded constant infusions of potassium chloride over 2 h (0.17 meq/min; 0.33 meq/min; 0.5 meq/min) or glucose ingestion (0.25 g/kg/15 min over a 2-h period)
C
Comparator
Baseline/control levels prior to infusion or ingestion
O
Outcome
Changes in plasma levels of aldosterone, renin activity, angiotensin II, cortisol, potassium, and sodiumsurrogate

Small, physiologic changes in extracellular potassium concentration play an important role in the acute regulation of aldosterone and renin secretion.

Cite This Study

Himathongkam et al. (1975) studied this question.

synapsesocial.com/papers/6a22729914901001fcff5d45https://doi.org/10.1210/jcem-41-1-153
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Simultaneous Potassium and Saline Loading on Plasma Aldosterone Levels1977 · 33 citations
  2. 2Potassium Regulates Angiotensin II-Induced Aldosterone Biosynthesis in Acutely Nephrectomized Rats*1984 · 5 citations
  3. 3Effects of High Potassium Diet on Angiotensin II Receptors and Angiotensin-Induced Aldosterone Production in Rat Adrenal Glomerulosa Cells*1980 · 29 citations
  4. 4Factors Related to Potassium Transport in Chronic Stable Renal Disease in Man1978 · 34 citations
  5. 5Potassium balance and the control of renin secretion1970 · 164 citations