What question did this study set out to answer?

To evaluate the relationships among plasma aldosterone, plasma renin activity, potassium excretion, and plasma potassium concentrations in individuals with normal versus reduced glomerular filtration rates.

June 1, 1978Clinical Science

Factors Related to Potassium Transport in Chronic Stable Renal Disease in Man

View Full Paper

Ask AI

Bookmark

Authors

TKThomas KahnJames J. Peters VA Medical Center DKD. M. KajiLincoln Medical Center GNG.L. NicolisUnited States Department of Veterans Affairs

Discussion

Member takes

Implication

Interventional study reveals impaired cellular potassium uptake in chronic renal disease, suggesting potassium excretion is independent of aldosterone elevation.

Key Points

To evaluate the relationships among plasma aldosterone, plasma renin activity, potassium excretion, and plasma potassium concentrations in individuals with normal versus reduced glomerular filtration rates.
Assessed 7 healthy control subjects and 12 patients with renal disease on a free diet for 5–10 days, followed by 5 days of daily 50 mmol potassium chloride supplementation.
Measured baseline plasma aldosterone in an additional comparative cohort of 22 hospital patients with normal glomerular filtration rate and 24 patients with reduced glomerular filtration rate.
Baseline plasma aldosterone and its rise during potassium chloride loading were similar between groups, indicating that potassium excretion in renal disease does not primarily rely on increased aldosterone.
During 50 mmol/day potassium chloride intake, potassium excretion increased similarly in both groups, but plasma potassium rose significantly from 4.7 to 5.4 mmol/l only in patients with renal disease, demonstrating impaired cellular potassium uptake.

Cite This Study

Kahn et al. (1978) studied this question.

synapsesocial.com/papers/6aa562ed86a9fcb249922105 https://doi.org/10.1042/cs0540661

View Full Paper

Ask AI

Bookmark

Implication

Interventional study reveals impaired cellular potassium uptake in chronic renal disease, suggesting potassium excretion is independent of aldosterone elevation.

Factors Related to Potassium Transport in Chronic Stable Renal Disease in Man

Discussion

Member takes

Implication

Key Points

Cite This Study

Factors Related to Potassium Transport in Chronic Stable Renal Disease in Man

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider