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August 1, 1969Endocrinology

Effect of Plasma K+ on the Secretion of Aldosterone

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Why the study?

Does intra-arterial infusion of potassium increase aldosterone secretion in conscious sheep?

Population

Conscious sheep with a single autotransplanted adrenal gland (both Na replete and Na depleted)

Comparison

Close intra-arterial infusion of [K+] enriched… vs Before infusion (baseline)

Design

Preclinical

Authors

JFJ W FunderExecutive Office of the PresidentJBJ. R. Blair‐WestThe University of MelbourneJCJ. P. CoghlanThe University of Melbourne

Discussion

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Overview

Supports direct K+-aldosterone coupling in conscious sheep; leaves open human translation and clinical relevance.

Structured PICO

Does intra-arterial infusion of potassium increase aldosterone secretion in conscious sheep?

P
Population
Conscious sheep with a single autotransplanted adrenal gland (both Na replete and Na depleted)
I
Intervention
Close intra-arterial infusion of [K+] enriched solutions (KCl) to the adrenal gland
C
Comparator
Before infusion (baseline)
O
Outcome
Secretion rates of aldosteronesurrogate

Elevation of plasma potassium directly stimulates aldosterone secretion in a dose-dependent manner in an in vivo sheep model.

Cite This Study

Funder et al. (1969) studied this question.

synapsesocial.com/papers/6a8555046615ae7d6e4e18cehttps://doi.org/10.1210/endo-85-2-381
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Sodium Concentration on Aldosterone Secretion by Isolated Perfused Canine Adrenal Glands*1984 · 50 citations
  2. 2THE DIRECT EFFECT OF INCREASED SODIUM CONCENTRATION IN ADRENAL ARTERIAL BLOOD ON CORTICOSTEROID SECRETION IN SODIUM DEFICIENT SHEEP1966 · 52 citations
  3. 3Multiplicative interaction between angiotensin II and K concentration in stimulation of aldosterone1984 · 56 citations
  4. 4Effect of Simultaneous Potassium and Saline Loading on Plasma Aldosterone Levels1977 · 33 citations
  5. 5Adrenal Hormones and the Regulation of Serum Potassium in Potassium-Loaded Adrenalectomized Dogs*1979 · 15 citations