Key result
In sodium-deficient sheep, increasing adrenal arterial blood sodium concentration by 8 mEq/l caused an approximately 25% decrease in aldosterone secretion rate during 1-3 hours.
Population
Sheep with autotransplanted adrenal glands made sodium deficient by continuous uncompensated loss of saliva…
Comparison
Adrenal arterial infusion of NaCl increasing… vs Infusions of hypertonic mannitol solution…
Design
Preclinical
Follow-up
1-6 hours
Authors
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Local adrenal sodium sensing modulates aldosterone in sodium deficiency; leaves open mechanisms and human relevance.
Local increase of sodium concentration in adrenal arterial blood transiently suppresses aldosterone hypersecretion in established sodium deficiency, indicating that local decrease of sodium is not the sole cause of aldosterone secretion in sodium deficiency.
Blair‐West et al. (1966) studied Sodium deficiency. Adrenal arterial infusion of sodium vs. Hypertonic mannitol solution / baseline was evaluated on Aldosterone secretion rate. In sodium-deficient sheep, increasing adrenal arterial blood sodium concentration by 8 mEq/l caused an approximately 25% decrease in aldosterone secretion rate during 1-3 hours.
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