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December 1, 1980Clinical Science

Inhibition by Bradykinin of the Vascular Effects of Pressor Hormones in the Canine Kidney: Relationship to Prostaglandins

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Why the study?

Does bradykinin reduce renal vasoconstriction induced by pressor hormones via prostaglandin synthesis in dogs?

Population

Dogs anaesthetized by sodium pentobarbital

Comparison

Renal arterial infusion of bradykinin or… vs Renal arterial injection of angiotensin II or…

Design

Preclinical

Authors

HSH SusićUniversity of Tennessee Health Science CenterANAlberto NasjlettiNew York Medical CollegeKMKafait U. MalikUniversity of Tennessee Health Science Center

Discussion

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Implication

Supports prostaglandin-dependent bradykinin effects on canine renal vasoconstriction; leaves open translation to human cardiorenal disease.

Key Points

  • To examine whether bradykinin blunts pressor hormone-induced renal vasoconstriction in the canine kidney and whether this action requires prostaglandin synthesis.
  • Injected bolus doses of angiotensin II or noradrenaline (0.06, 0.12, and 0.25 µg) into the renal artery of pentobarbital-anaesthetized dogs to induce vasoconstriction.
  • Infused bradykinin (10 ng/min/kg) or prostaglandin E2 (4 ng/min/kg) via the renal artery to measure changes in pressor-induced blood flow reduction.
  • Pretreated dogs with the prostaglandin synthesis inhibitor sodium meclofenamate (5 mg/kg) to determine prostaglandin dependence.
  • Angiotensin II and noradrenaline produced dose-dependent renal vasoconstriction and decreased renal blood flow.
  • Renal arterial infusion of either bradykinin or prostaglandin E2 reduced the vasoconstrictor and flow-lowering actions of both pressor hormones.
  • Pretreatment with sodium meclofenamate blunted the inhibitory action of bradykinin on renal vascular reactivity, but left the inhibitory effect of prostaglandin E2 intact.

Structured PICO

Does bradykinin reduce renal vasoconstriction induced by pressor hormones via prostaglandin synthesis in dogs?

P
Population
Dogs anaesthetized by sodium pentobarbital
I
Intervention
Renal arterial infusion of bradykinin (10 ng min-1 kg-1) or prostaglandin E2 (4 ng min-1 kg-1), with or without pretreatment with sodium meclofenamate (5 mg/kg)
C
Comparator
Renal arterial injection of angiotensin II or noradrenaline alone
O
Outcome
Renal blood flow and renal vasoconstrictionsurrogate

Bradykinin attenuates renal vasoconstriction from pressor hormones through a prostaglandin-dependent mechanism in a canine model.

Cite This Study

Susić et al. (1980) studied this question.

synapsesocial.com/papers/6a7c7a0e502bfbc401fd63aehttps://doi.org/10.1042/cs059145s
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Bradykinin effects on adrenergic transmission in the canine kidney: relation to prostaglandins1981 · 7 citations
  2. 2Inhibition by bradykinin of renal adrenergic effects in anesthetized rats1984 · 4 citations
  3. 3Increased Bradykinin Levels Accompany the Hemodynamic Response to Acute Inhibition of Angiotensin-Converting Enzyme in Dogs with Heart Failure1999 · 28 citations
  4. 4ROLE OF THE KALLIKREIN‐KININ SYSTEM IN THE RENAL EFFECTS OF ANGIOTENSIN‐CONVERTING ENZYME INHIBITION IN ANAESTHETIZED DOGS1981 · 26 citations
  5. 5Influence of Angiotensin-Converting Enzyme Inhibition on Sympathetic Neurotransmission: Possible Roles of Bradykinin and Prostaglandins1992 · 27 citations