What question did this study set out to answer?

To investigate the passage and metabolic clearance of bradykinin across the renal circulation in dogs and determine how kininase II inhibition impacts renal hemodynamics and excretory function.

July 1, 1975Circulation Research

Disappearance of bradykinin in the renal circulation of dogs. Effects of kininase inhibition.

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Authors

ANAlberto NasjlettiNew York Medical College JCJ Colina-ChourioUniversity of Zulia JMJ C McGiffNewYork–Presbyterian Hospital

Discussion

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Implication

Experimental study reveals that kininase II inhibition enhances bradykinin survival, renal blood flow, and natriuresis in dogs, indicating an intrarenal role for the kallikrein-kinin system.

Key Points

To investigate the passage and metabolic clearance of bradykinin across the renal circulation in dogs and determine how kininase II inhibition impacts renal hemodynamics and excretory function.
Infused bradykinin intra-arterially at doses of 5–200 ng/kg·min⁻¹ in chloralose-anesthetized dogs to measure renal blood flow and venous kinin concentrations.
Administered intravenous BPP9alpha (300 µg/kg), a kininase II inhibitor, to evaluate changes in bradykinin survival across the kidney, renal blood flow, urine flow, and electrolyte excretion.
Kininase II inhibition with BPP9alpha increased renal bradykinin survival from 12.72 ± 1.64% to 53.92 ± 7.48% (P < 0.001), which correlated with increases in renal blood flow (r = 0.92, P < 0.01), urine flow (r = 0.75, P < 0.01), and sodium excretion (r = 0.68, P < 0.01).
BPP9alpha alone elevated renal blood flow by 16% (P < 0.01), urine flow by 115% (P < 0.005), and sodium excretion by 167% (P < 0.02).
Venous kinin concentrations increased from 0.11 ± 0.03 to 0.24 ± 0.05 ng/mL (P < 0.005) and urinary kinin excretion rose from 4.1 ± 1.1 to 38.5 ± 12.2 ng/min (P < 0.02) following BPP9alpha administration.

Cite This Study

Nasjletti et al. (1975) studied this question.

synapsesocial.com/papers/6a76b873e8156ceda1adf78d https://doi.org/10.1161/01.res.37.1.59

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July 1, 1975Circulation Research

Disappearance of bradykinin in the renal circulation of dogs. Effects of kininase inhibition.

View Full Paper

Ask AI

Bookmark

Authors

ANAlberto NasjlettiNew York Medical College JCJ Colina-ChourioUniversity of Zulia JMJ C McGiffNewYork–Presbyterian Hospital

Discussion

Member takes

Implication

Experimental study reveals that kininase II inhibition enhances bradykinin survival, renal blood flow, and natriuresis in dogs, indicating an intrarenal role for the kallikrein-kinin system.

Key Points

To investigate the passage and metabolic clearance of bradykinin across the renal circulation in dogs and determine how kininase II inhibition impacts renal hemodynamics and excretory function.
Infused bradykinin intra-arterially at doses of 5–200 ng/kg·min⁻¹ in chloralose-anesthetized dogs to measure renal blood flow and venous kinin concentrations.
Administered intravenous BPP9alpha (300 µg/kg), a kininase II inhibitor, to evaluate changes in bradykinin survival across the kidney, renal blood flow, urine flow, and electrolyte excretion.
Kininase II inhibition with BPP9alpha increased renal bradykinin survival from 12.72 ± 1.64% to 53.92 ± 7.48% (P < 0.001), which correlated with increases in renal blood flow (r = 0.92, P < 0.01), urine flow (r = 0.75, P < 0.01), and sodium excretion (r = 0.68, P < 0.01).
BPP9alpha alone elevated renal blood flow by 16% (P < 0.01), urine flow by 115% (P < 0.005), and sodium excretion by 167% (P < 0.02).
Venous kinin concentrations increased from 0.11 ± 0.03 to 0.24 ± 0.05 ng/mL (P < 0.005) and urinary kinin excretion rose from 4.1 ± 1.1 to 38.5 ± 12.2 ng/min (P < 0.02) following BPP9alpha administration.

Cite This Study

Nasjletti et al. (1975) studied this question.

synapsesocial.com/papers/6a76b873e8156ceda1adf78d https://doi.org/10.1161/01.res.37.1.59

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