Why the study?
Does bradykinin infusion alter renal function in normal subjects, and is this effect modified by adrenergic blockade?
Population
9 normal subjects (5 for bradykinin infusion, 4 for norepinephrine infusion)
Design
Other
Authors
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Should not change practice; hypothesis-generating for bradykinin-adrenergic interactions in renal sodium handling.
Does bradykinin infusion alter renal function in normal subjects, and is this effect modified by adrenergic blockade?
Bradykinin alters renal function in normal humans, increasing sodium excretion at low doses, an effect that is reversed during adrenergic blockade, suggesting a complex physiologic role in renal control.
Gill et al. (1965) studied this question.
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