What question did this study set out to answer?

This research aims to explore how bradykinin influences renal vascular responses to adrenergic stimuli.

April 1, 1984AJP Renal Physiology

Inhibition by bradykinin of renal adrenergic effects in anesthetized rats

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Population

Pentobarbital-anesthetized rats

Comparison

Infusion of bradykinin into the renal artery… vs Baseline conditions and response to arachidonic…

Design

Preclinical

Authors

KIK InokuchiShowa University KMKafait U. MalikUniversity of Tennessee Health Science Center

Discussion

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Implication

Bradykinin vasodilation in rat kidney appears prostaglandin-independent; leaves open relevance to human renal vascular control or therapy.

Key Points

This research aims to explore how bradykinin influences renal vascular responses to adrenergic stimuli.
Examined the effect of bradykinin on renal blood flow in pentobarbital-anesthetized rats.
Administered cyclooxygenase inhibitors sodium meclofenamate or indomethacin before treatment.
Analyzed responses to renal nerve stimulation and norepinephrine infusion.
Bradykinin reduced both basal renal vascular resistance and the increase due to nerve stimulation or norepinephrine.
Arachidonic acid also decreased renal vascular resistance but only when bradykinin was not present.
Effects of bradykinin on renal vasodilation were independent of prostaglandin synthesis.

Structured PICO

Population

Pentobarbital-anesthetized rats

Intervention

Infusion of bradykinin (10 ng/kg/min) into the renal artery, with or without pretreatment with cyclooxygenase inhibitors (sodium meclofenamate or indomethacin)

Comparator

Baseline conditions and response to arachidonic acid (5 mcg/kg/min)

Outcome

Change in renal vascular resistance and renal blood flow elicited by renal nerve stimulation and injected norepinephrinesurrogate

Bradykinin produces renal vasodilation and inhibits adrenergically induced renal vasoconstriction in vivo via a mechanism independent of prostaglandin synthesis.

Cite This Study

Inokuchi et al. (1984) studied this question.

synapsesocial.com/papers/6a72c802a7fbea1e4408bd6f https://doi.org/10.1152/ajprenal.1984.246.4.f387

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Implication

Bradykinin vasodilation in rat kidney appears prostaglandin-independent; leaves open relevance to human renal vascular control or therapy.

Inhibition by bradykinin of renal adrenergic effects in anesthetized rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Inhibition by bradykinin of renal adrenergic effects in anesthetized rats

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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