Why the study?
Does indomethacin pretreatment suppress bradykinin-induced renin release in anesthetized rats?
Population
Pentobarbital-anesthetized rats
Comparison
Intrarenal infusion of bradykinin after… vs Intrarenal infusion of bradykinin without…
Design
Preclinical
Authors
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Supports prostaglandin mediation of bradykinin-renin effects in rats; extends mechanistic data but leaves open human relevance.
Does indomethacin pretreatment suppress bradykinin-induced renin release in anesthetized rats?
Bradykinin-induced renin release in rats appears to be mediated by prostaglandins, as it is suppressed by the cyclooxygenase inhibitor indomethacin.
Suzuki et al. (1984) studied this question.
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