December 1, 1979AJP Renal Physiology

Bradykinin-induced renal hemodynamic alterations: renin and prostaglandin relationships

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Why the study?

Does the renin-angiotensin system modify the renal vasomotor response to bradykinin?

Population

Unspecified preclinical model

Comparison

Renal arterial bradykinin infusion for up to 120… vs Baseline/control values

Design

Preclinical

Follow-up

120 minutes

Authors

WFWalter FlamenbaumBrigham and Women's Hospital JGJohn A. GagnonWalter Reed Army Institute of Research PRPeter W. RamwellGeorgetown University

Discussion

Member takes

Implication

Suggests angiotensin II blunts sustained bradykinin renal vasodilation in animals; leaves open relevance to human kidney disease.

Structured PICO

Does the renin-angiotensin system modify the renal vasomotor response to bradykinin?

Population

Unspecified preclinical model

Intervention

Renal arterial bradykinin infusion (80 ng.kg-1.min-1) for up to 120 min, alone or after prostaglandin synthetase inhibition (meclofenamate) or competitive inhibition of angiotensin II

Comparator

Baseline/control values

Outcome

Renal blood flow (RBF) and secretory rates of renin and prostaglandinssurrogate

The lack of sustained renal hyperemia after bradykinin infusion is related to increased renin-angiotensin system activity, demonstrating a complex interaction between bradykinin, prostaglandins, and renin.

Cite This Study

Flamenbaum et al. (1979) studied this question.

synapsesocial.com/papers/6a87c078ae2ee8767cfe7565 https://doi.org/10.1152/ajprenal.1979.237.6.f433

View Full Paper

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Bradykinin-induced renal hemodynamic alterations: renin and prostaglandin relationships

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Bradykinin-induced renal hemodynamic alterations: renin and prostaglandin relationships

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider