Key result
In the rat isolated perfused kidney, the vasodilator response to bradykinin is mediated by both nitric oxide and arachidonic acid metabolites, with the latter accounting for up to 70% of the effect.
Population
Rat isolated perfused kidney, preconstricted with phenylephrine
Comparison
Inhibition of nitric oxide generation… vs Vasodilator responses to acetylcholine or…
Design
Preclinical
Authors
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Should not change clinical vasodilator use; leaves open translation of rat kidney mechanisms to human physiology.
The vasodilator effect of bradykinin in the rat kidney is heavily dependent on arachidonic acid metabolites generated via cytochrome P450, in addition to nitric oxide.
Fulton et al. (1992) studied Rat isolated perfused kidney. Inhibitors of NO, cyclo-oxygenase, and cytochrome P450 was evaluated on Vasodilator responses to bradykinin. In the rat isolated perfused kidney, the vasodilator response to bradykinin is mediated by both nitric oxide and arachidonic acid metabolites, with the latter accounting for up to 70% of the effect.
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