Why the study?
Does inhibition of calcium-activated potassium channels reduce the vasodilator effect of bradykinin in isolated rat kidneys?
Population
Isolated, perfused rat kidneys preconstricted with phenylephrine and treated with NG-nitro-L-arginine and…
Comparison
Potassium channel inhibitors vs Vasodilator responses to cromakalim and…
Design
Preclinical
Authors
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May implicate IKCa channels in renal bradykinin responses; leaves open translation to human physiology or therapy.
Does inhibition of calcium-activated potassium channels reduce the vasodilator effect of bradykinin in isolated rat kidneys?
The study demonstrates that intermediate conductance calcium-activated potassium channels mediate the NO- and prostaglandin-independent vasodilator effect of bradykinin in the rat kidney.
Rapacon et al. (1996) studied this question.
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