The effects of endothelium‐dependent vasodilators on cardiac output and their distribution in the anaesthetized rat: a comparison with sodium nitroprusside
Why the study?
Do endothelium-dependent vasodilators (acetylcholine and bradykinin) affect cardiac output and its distribution differently than sodium nitroprusside in anaesthetized rats?
Population
Anaesthetized, vagotomised rat preparation
Comparison
Acetylcholine and bradykinin vs Sodium nitroprusside
Design
Preclinical
Authors
Discussion
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Implication
Warrants further preclinical study of vasodilator selectivity; leaves open translation to human hemodynamics.
Structured PICO
Do endothelium-dependent vasodilators (acetylcholine and bradykinin) affect cardiac output and its distribution differently than sodium nitroprusside in anaesthetized rats?
P
Population
Anaesthetized, vagotomised rat preparation
I
Intervention
Acetylcholine and bradykinin (with or without indomethacin 4 mg kg-1)
C
Comparator
Sodium nitroprusside
O
Outcome
Cardiac output and its distribution (measured by 113Sn-labelled microspheres)surrogate
Bradykinin reduces total peripheral resistance without reducing cardiac output in rats, demonstrating differential regional vascular sensitivities compared to acetylcholine and sodium nitroprusside.
Cite This Study
Thomas et al. (1988) studied this question.