January 1, 1985The Japanese Journal of PharmacologyOpen Access

No Role for Prostaglandins and Bradykinin in the Autoregulation of Renal Blood Flow

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Population

Anesthetized dogs (pump-perfused kidney model)

Comparison

Infusion of prostaglandin E2, sodium… vs Baseline (before infusion)

Design

Preclinical

Authors

NONobuyuki OgawaNational Institute of Technology, Gifu College HOHiroshi OnoNingbo University

Discussion

Member takes

Implication

Does not support targeting these pathways for renal autoregulation; leaves open translation to human physiology.

Structured PICO

Population

Anesthetized dogs (pump-perfused kidney model)

Intervention

Infusion of prostaglandin E2 (30 and 100 ng/min), sodium arachidonate (200 and 500 micrograms/min), bradykinin (100 and 300 ng/min) into the renal artery, or intravenous captopril (1 mg/kg) or indomethacin (2.5 mg/kg)

Comparator

Baseline (before infusion)

Outcome

Renal blood flow autoregulation against pressure changes between 60 and 200 mmHgsurrogate

Prostaglandins and bradykinin do not play a role in the autoregulation of renal blood flow in dogs, despite their vasodilatory effects.

Cite This Study

Ogawa et al. (1985) studied this question.

synapsesocial.com/papers/6a8ae23ef07ad6ed43b1ee63 https://doi.org/10.1254/jjp.39.349

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