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January 1, 1992Journal of Cardiovascular Pharmacology

Influence of Angiotensin-Converting Enzyme Inhibition on Sympathetic Neurotransmission: Possible Roles of Bradykinin and Prostaglandins

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Population

Canine skeletal muscle in situ and in vitro models

Design

Review

Authors

JSJonas SchwielerElectrophysiologyPHPaul HjemdahlPreventive Cardiology

Discussion

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Implication

ACE inhibitor effects on sympathetic tone involve multiple pathways in canine models; leaves open translation to human cardiovascular therapy.

Structured PICO

P
Population
Canine skeletal muscle in situ and in vitro models
I
Intervention
Angiotensin-converting enzyme (ACE) inhibitors
O
Outcome
Sympathetic neurotransmission modulationsurrogate

The effects of ACE inhibitors on sympathetic neurotransmission are mediated not only by reduced Ang II formation but also by enhanced bradykinin and prostaglandin activity.

Limitations

  • Most studies performed under in vitro conditions with high doses of bradykinin, questioning physiological relevance
  • Lack of specific and effective bradykinin receptor antagonists until recently
  • Difficulties with measurements of true plasma or tissue levels of bradykinin
  • Species and/or tissue differences in responses to bradykinin

Cite This Study

Schwieler et al. (1992) studied this question.

synapsesocial.com/papers/6a76b6112e130d02afec2340https://doi.org/10.1097/00005344-199200209-00009
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Kinins, Receptors, Kininases and Inhibitors Where Did They Lead Us?2001 · 46 citations
  2. 2Heterogeneity of Endothelium-Dependent Vasodilator Effects of Angiotensin-Converting Enzyme Inhibitors: Role of Bradykinin Generation During ACE Inhibition1992 · 60 citations
  3. 3Role of Bradykinin in the Cardiac Effects of Angiotensin-Converting Enzyme Inhibitors1992 · 109 citations
  4. 4Converting enzyme inhibition modulates sympathetic neurotransmission in vivo via multiple mechanisms1993 · 33 citations
  5. 5Bradykinin effects on adrenergic transmission in the canine kidney: relation to prostaglandins1981 · 7 citations