February 1, 1999AJP Renal Physiology

Kinin influences on renal regional blood flow responses to angiotensin-converting enzyme inhibition in dogs

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Why the study?

Does bradykinin B2 receptor blockade alter the renal regional blood flow responses to ACE inhibition in dogs on normal versus low salt diets?

Population

28 dogs maintained on either a normal-salt diet or a low-salt diet

Comparison

ACE inhibition evaluated before or after… vs Responses compared between normal-salt and…

Design

Preclinical

Authors

SOSophia A. OmoroTulane University DMDewan S. A. MajidTulane University SESamir S. El‐DahrTulane University

Discussion

Member takes

Implication

Salt-dependent bradykinin mediation of ACEI renal vasodilation in dogs; leaves open human translation and clinical relevance.

Structured PICO

Does bradykinin B2 receptor blockade alter the renal regional blood flow responses to ACE inhibition in dogs on normal versus low salt diets?

Population

28 dogs maintained on either a normal-salt diet (0.63%, 3 days, n = 14) or a low-salt diet (0.01%, 5 days, n = 14)

Intervention

ACE inhibition (enalaprilat, 33 micrograms/kg/min) evaluated before or after treatment with the bradykinin B2 receptor blocker icatibant (100-300 micrograms)

Comparator

Responses compared between normal-salt and low-salt diet groups, and before vs. after icatibant treatment

Outcome

Relative changes in renal medullary blood flow (MBF) and cortical blood flow (CBF)surrogate

In dogs, renal vasodilatory responses to ACE inhibition are primarily due to reduced angiotensin II under normal salt intake, but are markedly dependent on bradykinin B2 receptor activation under low salt intake.

Cite This Study

Omoro et al. (1999) studied this question.

synapsesocial.com/papers/6a8afd2552e1a91077e9547c https://doi.org/10.1152/ajprenal.1999.276.2.f271

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February 1, 1999AJP Renal Physiology

Kinin influences on renal regional blood flow responses to angiotensin-converting enzyme inhibition in dogs

View Full Paper

Ask AI

Bookmark

Why the study?

Does bradykinin B2 receptor blockade alter the renal regional blood flow responses to ACE inhibition in dogs on normal versus low salt diets?

Population

28 dogs maintained on either a normal-salt diet or a low-salt diet

Comparison

ACE inhibition evaluated before or after… vs Responses compared between normal-salt and…

Design

Preclinical

Authors

SOSophia A. OmoroTulane University DMDewan S. A. MajidTulane University SESamir S. El‐DahrTulane University

Discussion

Member takes

Implication

Salt-dependent bradykinin mediation of ACEI renal vasodilation in dogs; leaves open human translation and clinical relevance.

Structured PICO

Does bradykinin B2 receptor blockade alter the renal regional blood flow responses to ACE inhibition in dogs on normal versus low salt diets?

Population

28 dogs maintained on either a normal-salt diet (0.63%, 3 days, n = 14) or a low-salt diet (0.01%, 5 days, n = 14)

Intervention

ACE inhibition (enalaprilat, 33 micrograms/kg/min) evaluated before or after treatment with the bradykinin B2 receptor blocker icatibant (100-300 micrograms)

Comparator

Responses compared between normal-salt and low-salt diet groups, and before vs. after icatibant treatment

Outcome

Relative changes in renal medullary blood flow (MBF) and cortical blood flow (CBF)surrogate

Cite This Study

Omoro et al. (1999) studied this question.

synapsesocial.com/papers/6a8afd2552e1a91077e9547c https://doi.org/10.1152/ajprenal.1999.276.2.f271

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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