Why the study?
Does prostaglandin synthesis inhibition block the macula densa mechanism of renin release in dogs?
Population
Uninephrectomized, anaesthetized dogs with functionally isolated macula densa mechanism
Comparison
Indomethacin or meclofenamic acid during a 50%… vs 50% reduction in renal perfusion pressure…
Design
Preclinical
Follow-up
10 min
Authors
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Prostaglandin dependence of macula densa renin release confirmed in dogs; leaves open translation to human physiology or therapy.
Does prostaglandin synthesis inhibition block the macula densa mechanism of renin release in dogs?
The macula densa mechanism of renin release is dependent on prostaglandin synthesis.
Gerber et al. (1981) studied this question.
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