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March 1, 1979Endocrinology

Mechanism of Suppression of Plasma Renin Activity by Centrally Administered Angiotensin II*

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Why the study?

Does intraventricular angiotensin II suppress plasma renin activity via increased vasopressin or arterial blood pressure in anesthetized dogs?

Population

21 pentobarbital-anesthetized dogs with cannulas placed in the third cerebral ventricle

Comparison

Intraventricular injection of angiotensin II vs Baseline values and comparison between intact…

Design

Preclinical

Follow-up

30 min

Authors

SMSAMUEL A. MALAYANLKL. C. KeilDRD. J. Ramsay

Discussion

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Overview

Central angiotensin II effects on renin in dogs appear vasopressin-dependent; leaves open translation to human cardiovascular regulation.

Structured PICO

Does intraventricular angiotensin II suppress plasma renin activity via increased vasopressin or arterial blood pressure in anesthetized dogs?

P
Population
21 pentobarbital-anesthetized dogs with cannulas placed in the third cerebral ventricle (12 intact, 9 acutely hypophysectomized)
I
Intervention
Intraventricular injection of angiotensin II (500 ng)
C
Comparator
Baseline values (pre-injection) and comparison between intact and hypophysectomized dogs
O
Outcome
Changes in plasma renin activity (PRA), plasma vasopressin concentration, and mean arterial pressure 30 min after injectionsurrogate

Centrally administered angiotensin II suppresses plasma renin activity likely via an increase in plasma vasopressin rather than an increase in arterial pressure.

Cite This Study

MALAYAN et al. (1979) studied this question.

synapsesocial.com/papers/6a8932017c664faad1127126https://doi.org/10.1210/endo-104-3-672
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Plasma Renin Activity Following Central Infusion of Angiotensin II and Altered CSF Sodium Concentration in the Conscious Goat1976 · 36 citations
  2. 2The Effects of Intracerebroventricular Administration of Renin on Drinking and Blood Pressure<sup>1</sup>1975 · 79 citations
  3. 3Effects of Centrally Administered Angiotensin II on Salt and Water Excretion2008 · 40 citations
  4. 4Evidence for a Central Mechanism in Angiotensin Induced Hypertension.1961 · 384 citations
  5. 5Inhibition of Renin Release by Vasopressin and Angiotensin1967 · 104 citations