Central administration of angiotensin II reduces plasma renin activity and increases natriuresis in cats, suggesting a neurogenic component and a reciprocal relationship between CSF renin activity and PRA.
Answers are grounded in this paper and cite their sources.
Suggests renal nerves mediate central angiotensin II effects in cats; leaves open relevance to human hypertension.
Cerebroventricular administration of angiotensin II elevated arterial pressure and reduced plasma renin activity (PRA) in renal venous blood in anesthetized cats. Further, there was an increase in the concentration of urinary sodium, as well as the rate of Na+ excretion. Acute renal denervation significantly reduced the effects of central angiotensin II on the PRA and on the natriuresis. The data suggested involvement of a neurogenic component in these effects. Further, it appears that there may be a reciprocal relationship between CSF renin activity and PRA.
No takes yet. Share an insight, caveat, or question.
Lokhandwala et al. (1978) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: