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December 1, 1984AJP Renal Physiology

Effect of renal denervation on the suppression of renin secretion by vasopressin in conscious dogs

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Why the study?

Does bilateral renal denervation block the suppression of plasma renin activity by vasopressin in conscious dogs?

Population

7 conscious dogs

Comparison

Bilateral renal denervation vs Before bilateral renal denervation

Design

Preclinical

Follow-up

1 to 3 weeks following renal denervation

Authors

LGLisa C. GregoryAmes Research CenterIRI. A. ReidThe University of Sydney

Discussion

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Implication

Renal nerve mediation of vasopressin effects on renin in dogs leaves open translation to human cardiorenal physiology.

Structured PICO

Does bilateral renal denervation block the suppression of plasma renin activity by vasopressin in conscious dogs?

P
Population
7 conscious dogs
I
Intervention
Bilateral renal denervation
C
Comparator
Before bilateral renal denervation (within-subject comparison)
O
Outcome
Plasma renin activity (PRA) suppression by vasopressin (AVP) and angiotensin II (ANG II)surrogate

Bilateral renal denervation blocks the suppression of plasma renin activity by vasopressin in conscious dogs, indicating this suppression is a reflex response mediated by renal nerves.

Cite This Study

Gregory et al. (1984) studied this question.

synapsesocial.com/papers/6a901b22b71d06dae589d3fbhttps://doi.org/10.1152/ajprenal.1984.247.6.f881
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effect of Renal Denervation on Release and Content of Renin in Anesthetized Dogs1967 · 27 citations
  2. 2Role of intrarenal ANG II in reflex neural stimulation of plasma renin activity and renal sodium reabsorption1993 · 10 citations
  3. 3Mechanisms Regulating Renin Release in Dogs with Thoracic Caval Constriction1972 · 35 citations
  4. 4Arterial baroreceptors control plasma vasopressin responses to graded hypotension in conscious dogs2000 · 23 citations
  5. 5Neurogenic control of renal function in response to graded nonhypotensive hemorrhage in conscious dogs1993 · 24 citations