March 1, 1978The Journal of PhysiologyOpen Access

Drinking and haemodynamic changes induced in the dog by intracranial injection of components of the renin‐angiotensin system.

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Population

Water-replete dogs

Comparison

Intracranial injections of components of the… vs Isotonic saline, bradykinin…

Design

Preclinical

Authors

JFJ. T. FitzsimonsUniversity of Cambridge JKJohn KucharczykLong Island University

Discussion

Member takes

Implication

Central angiotensin II potently drives thirst in dogs; leaves open its role in human fluid homeostasis and hypertension.

Structured PICO

Population

Water-replete dogs

Intervention

Intracranial injections of components of the renin-angiotensin system (angiotensin II, angiotensin I, synthetic renin substrate, angiotensin III, and renin)

Comparator

Isotonic saline, bradykinin, eledosin-hexapeptide, oxytocin, and prostaglandin F2alpha

Outcome

Amount of water drunk and changes in blood pressuresurrogate

Intracranial angiotensin II is a potent dipsogen in dogs, eliciting drinking behavior from widespread brain regions without direct peripheral hemodynamic changes.

Cite This Study

Fitzsimons et al. (1978) studied this question.

synapsesocial.com/papers/6a816ba7adfa6baaaee1d4cd https://doi.org/10.1113/jphysiol.1978.sp012244

View Full Paper

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Drinking and haemodynamic changes induced in the dog by intracranial injection of components of the renin‐angiotensin system.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Drinking and haemodynamic changes induced in the dog by intracranial injection of components of the renin‐angiotensin system.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider