Key result
Brain-restricted alpha-adrenergic blockade with phentolamine blocks the angiotensin II pressor response without affecting drinking.
Why the study?
The neurotransmitters mediating the blood pressure increase and drinking response to central angiotensin II injection were unclear.
The pressor effect of central angiotensin II is mediated by noradrenergic stimulation of alpha-receptors, whereas the drinking response is not mediated by monoamines.
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Central alpha-adrenergic blockade dissociates Ang II pressor from drinking responses in animals; leaves open translation to human cardiovascular or fluid regulation.
Camacho et al. (1981) studied this question. Pharmacologic manipulations of monoamines with angiotensin II was evaluated on Blood pressure (pressor response) and drinking (dipsogenic response). Alpha-adrenergic blockade with phentolamine restricted to the brain blocked the pressor response to angiotensin II in a dose-related manner, while drinking remained unaffected.
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