What question did this study set out to answer?

Evaluate evidence that angiotensin II raises blood pressure by modulating autonomic nervous system activity and stimulating central sympathetic pathways.

January 1, 1997Clinical and Experimental Pharmacology and Physiology

Long‐term Sympatho‐excitatory Effect of Angiotensin Ii: A Mechanism of Spontaneous and Renovascular Hypertension

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Population

Experimental and clinical models of spontaneous and renovascular hypertension

Design

Review

Authors

GFGregory D. FinkMichigan United

Discussion

Member takes

Implication

Central AngII sympathoexcitation may contribute to renovascular hypertension; hypothesis-generating and requires prospective validation before clinical translation.

Key Points

Evaluate evidence that angiotensin II raises blood pressure by modulating autonomic nervous system activity and stimulating central sympathetic pathways.
Narrative synthesis of experimental animal and clinical studies investigating autonomic actions of circulating and brain-derived angiotensin II.
Neuroanatomical evaluation focused on brainstem pre-motor neurons in the rostral ventrolateral medulla and circumventricular sensory regions.
Circulating and brain-derived angiotensin II activate sympathetic pre-motor neurons in the rostral ventrolateral medulla to drive sustained pressor responses.
Circulating angiotensin II acts via the area postrema to induce neurogenic vasoconstriction in renovascular hypertension, while concomitant baroreflex modulation masks its outward presentation.

Structured PICO

Population

Experimental and clinical models of spontaneous and renovascular hypertension

Intervention

Angiotensin II (mechanistic review)

Angiotensin II contributes to hypertension not only through direct vascular and renal effects but significantly via central sympatho-excitatory pathways.

Cite This Study

Gregory D. Fink (1997) studied this question.

synapsesocial.com/papers/6a11cdb7a50709dd2cdcd49d https://doi.org/10.1111/j.1440-1681.1997.tb01789.x

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Implication

Central AngII sympathoexcitation may contribute to renovascular hypertension; hypothesis-generating and requires prospective validation before clinical translation.

Long‐term Sympatho‐excitatory Effect of Angiotensin Ii: A Mechanism of Spontaneous and Renovascular Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Long‐term Sympatho‐excitatory Effect of Angiotensin Ii: A Mechanism of Spontaneous and Renovascular Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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