January 1, 1984AJP Regulatory Integrative and Comparative Physiology

Mechanisms of the central pressor action of angiotensin II in conscious rats

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Population

Conscious unrestrained rats

Comparison

Angiotensin II and angiotensin I infused via the… vs Angiotensin II and angiotensin I infused via the…

Design

Preclinical

Authors

RLRodney W. LappeAtrium Health Wake Forest Baptist MBMichael J. BrodyUniversity of the Sciences

Discussion

Member takes

Implication

Central ANG II effects on vasoconstriction merit mechanistic study; leaves open human hypertension relevance.

Structured PICO

Population

Conscious unrestrained rats

Intervention

Angiotensin II (ANG II) and angiotensin I (ANG I) infused via the carotid artery

Comparator

Angiotensin II (ANG II) and angiotensin I (ANG I) infused via the abdominal aorta

Outcome

Regional vascular resistance responses (hindquarters, renal, and mesenteric vascular beds) and arterial pressuresurrogate

Central actions of angiotensin II induce neurally mediated vasoconstriction in multiple vascular beds, independent of peripheral effects or central conversion of blood-borne angiotensin I.

Cite This Study

Lappe et al. (1984) studied this question.

synapsesocial.com/papers/6a8488bada9d2319e77c0c5d https://doi.org/10.1152/ajpregu.1984.246.1.r56

View Full Paper

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Mechanisms of the central pressor action of angiotensin II in conscious rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanisms of the central pressor action of angiotensin II in conscious rats

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider