What question did this study set out to answer?

To determine whether circulating renin is present in pressor amounts sufficient to sustain two-kidney Goldblatt renal hypertension.

June 1, 1975Circulation Research

Role of renin in the pathogenesis of renal hypertension.

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Why the study?

Does renin play a role in the pathogenesis of the acute or semiacute phase of renal hypertension in rats?

Population

Rats with two-kidney Goldblatt hypertension present for 4 to 21 days

Comparison

Removal of ischemic kidney and immediate… vs Pre-nephrectomy state

Design

Preclinical

Authors

OGOm P. GulatiUniversity of Geneva OCOscar A. CarreteroGeneral / Preventive / Lipids NONarendra B. OzaBoston University

Discussion

Member takes

Implication

Renin’s pressor-range levels in rat renal hypertension support its acute-phase role; human translation remains untested.

Key Points

To determine whether circulating renin is present in pressor amounts sufficient to sustain two-kidney Goldblatt renal hypertension.
Induced two-kidney Goldblatt hypertension in rats for 4 to 21 days prior to surgical excision of the ischemic kidney.
Administered an immediate replacement infusion of rat renin controlled by a feedback mechanism set to maintain pre-nephrectomy mean blood pressure.
Assayed plasma renin activity (PRA) before nephrectomy and at the conclusion of the exogenous renin infusion.
Exogenous renin replacement prevented the remission of hypertension following unilateral nephrectomy of the ischemic kidney.
Plasma renin activity at the conclusion of the infusion matched pre-nephrectomy baseline levels, confirming circulating renin is within the pressor range.
No correlation was detected between plasma renin activity and blood pressure levels, indicating that additional non-renin factors may contribute.

Structured PICO

Does renin play a role in the pathogenesis of the acute or semiacute phase of renal hypertension in rats?

Population

Rats with two-kidney Goldblatt hypertension present for 4 to 21 days

Intervention

Removal of ischemic kidney and immediate infusion of rat renin regulated by feedback to maintain mean blood pressure

Comparator

Pre-nephrectomy state

Outcome

Plasma renin activity (PRA) and mean blood pressuresurrogate

Circulating renin levels in a rat model of renal hypertension are within the pressor range, supporting its role in the acute or semiacute phase of the disease.

Limitations

Participation of other factors cannot be ruled out since no correlation was found between PRA and blood pressure

Cite This Study

Gulati et al. (1975) studied this question.

synapsesocial.com/papers/6a8d1aebb4e2d843785be3d2 https://doi.org/10.1161/01.res.36.6.187

View Full Paper

Ask AI

Bookmark

Role of renin in the pathogenesis of renal hypertension.

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Role of renin in the pathogenesis of renal hypertension.

Discussion

Member takes

Implication

Key Points

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider