Key result
Pressor responses to exogenous renin and angiotensin were significantly decreased in hypertensive rats with a contralateral kidney but normal in those with a sole clipped kidney.
Population
Unanesthetized rats made hypertensive by clipping one renal artery with and without contralateral nephrectomy
Comparison
Subcutaneous injections of renin and angiotensin vs Rats with a sole clipped kidney vs rats with one…
Design
Preclinical
Follow-up
Up to 3 months after clipping; up to 72 hours after kidney…
Authors
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Hypothesis-generating in renal hypertension models; leaves open translation to human renovascular disease.
In renal hypertensive rats, pressor responses to exogenous renin and angiotensin are inversely related to endogenous renin levels and are transiently enhanced following removal of the clipped kidney.
Aoki et al. (2008) studied Renal hypertension. Subcutaneous injections of renin and angiotensin vs. Rats with a sole clipped kidney was evaluated on Pressor responses. Pressor responses to exogenous renin and angiotensin were significantly decreased in hypertensive rats with a contralateral kidney but normal in those with a sole clipped kidney.
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